Custom Peptides
Cayman Chemical SalIcylcurcumIn 10mg
A synthetic curcuminoid with antioxidant and anticarcinogenic properties; increases the activity of quinone reductase in mouse hepatoma cells in a dose-dependent fashion, doubling activity at 0.3 μM salicylcurcumin
Cayman Chemical SapacItabIn 10mg
A prodrug form of CNDAC; reduces tumor volume in an MV4-11 mouse xenograft model at 5 and 15 mg/kg alone or in combination with SAHA
Cayman Chemical PseudolarIc AcId B 10mg
A diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant; has antifungal activities and diverse effects that are relevant to cancer therapy
Cayman Chemical 3R 5RRosuvastatIncalcIum 10mg
A potential impurity found in bulk preparations of rosuvastatin
Cayman Chemical HederacosIde C 10mg
A saponin with anti-inflammatory activity that inhibits AChE (IC50 = 31.3 μM); inhibits the mutagenicity induced by aflatoxin B1 in S. typhimurium agar cultures from 21-67% at 0.5-5 μg per plate; reduces TNF-α, IL-1β, IL-6, COX-2, and NOS levels and IRAK1 activity in LPS-stimulated mouse peritoneal macrophages at 5-10 μM; reduces carrageenan-induced acute edema in the rat hind paw by 37% compared to vehicle control at 0.02 mg/kg; reduces scopolamine-induced memory impairment and increases latency in a passive avoidance test and spontaneous alteration in a Y-maze in mice by 100 and 59%, respectively, at 40 mg/kg; reduces serum levels of TNF-α and IL-1β by 60 and 65%, respectively, in LPS-challenged mice at 5 mg/kg
Cayman Chemical LY2228820mesylate 10mg
A potent inhibitor of p38α MAP kinase (IC50 = 7 nM for human recombinant p38α); inhibits LPS-induced TNF-α production in murine peritoneal macrophages and reduces phosphorylation of MK2 in RAW 264.7 cells (IC50s = 5.2 and 34.3 nM, respectively); inhibits TNF-α production in LPS-treated mice and reduces paw swelling and cartilage destruction in a rat model of chronic inflammation (TMED50s = <1, 1.5, and 1.5 mg/kg, respectively)
Cayman Chemical BenocyclIdIn-d10 10mg
An internal standard for the quantification of benocyclidine by GC- or LC-MS
Cayman Chemical 15 S-Latnoprost 10mg
A 15(S) isomer of latanoprost; reduces IOP in cynomolgus monkeys and does not induce eye irritation in cats when applied topically at 3 UG/eye; a potential impurity in commercial preparations of latanoprost
Cayman Chemical MocetInostat 10mg
An orally available HDAC inhibitor that selectively targets HDAC1 and 2 (IC50s = 0.15 and 0.29 µM, respectively), less potently inhibits HDAC3 and 11 (IC50s = 1.66 and 0.59 µM, respectively); induces hyperacetylation of histones, causes cell cycle blockade, and induces apoptosis in cancer cells in vitro