Custom Peptides
Cayman Chemical SpIraprIlhydrochlorIde 10mg
An ACE inhibitor (IC50 = 67 nM) and a prodrug form of spiraprilat; inhibits the angiotensin I-induced pressor response in rats and dogs (ID50s = 16 and 262 UG/kg, respectively); decreases systolic blood pressure and left ventricular hypertrophy and induces angiogenesis in spontaneously hypertensive rats 5 mg/kg
Cayman Chemical Lnnamvr 10mg
An inhibitor of influenza neuraminidases and an active metabolite of laninamivir octanoate; inhibits the neuraminidases from influenza A H1N1, H2N2, and H3N2 strains (mean IC50s = 2.49, 11.4, and 16.7 nM, respectively) and influenza B Victoria and Yamagata strains (mean IC50s = 18.9 nM for both); increases survival in a mouse model of lethal influenza H1N1 infection when administered intranasally at 69 UG/kg
Cayman Chemical KatcalcIntrIfluoroacetate 10mg
An endogenous peptide; expressed in, and secreted from, thyroid parafollicular cells in humans; plasma levels are increased in patients with medullary thyroid carcinoma
Cayman Chemical Tocopherol 10mg
A biologically active form of vitamin E; inhibits the growth of DU145, LNCaP, and Caco-2 cancer cells at 25 µM; reduces airway eosinophil infiltration and levels of IL-6, IL-5, IL-13, and CCL2 in a rat model of ovalbumin-induced allergic inflammation and a rat model of ovalbumin- and ozone-induced asthma at 100 mg/kg; reduces lipid peroxidation in vitamin E-depleted, iron-loaded rats
Cayman Chemical Huperzn B 10mg
An alkaloid with neuroprotective activity; selectively binds to AChE over BChE (IC50s = 8.2 and 157 µM, respectively); an antagonist at the NMDA receptor (IC50 = 316.6 µM); increases the viability of PC12 cells in a model of hydrogen peroxide-induced cell injury at 0.1-100 µM; increases GPX and CAT activities, and decreases MDA levels, in PC12 cells in a model of hydrogen peroxide-induced cell injury at 10-100 µM
Cayman Chemical 1-O-AcetylbrItnIlacton 10mg
A sesquiterpene lactone with diverse biological activities; inhibits LPS-induced production of PGE2 and nuclear translocation of NF-κB in primary rat aorta VSMCs; inhibits VEGF-induced capillary tube formation in HUVECs at 5 and 10 µM; reduces tumor growth in an A549 mouse xenograft model at 12 mg/kg per day
Cayman Chemical Swerta bmaculta Swertsn 10mg
A flavonoid C-glycoside with diverse biological activities; inhibits SGLT2 in HEK293 at 7.5 UG/ml; is an adenosine A1 receptor antagonist (IC50 = 137 µM); inhibits HBV replication in HepG2 2.2.15 cells at 0.2-5 µM; decreases blood glucose levels in a mouse model of streptozotocin-induced diabetes; prevents scopolamine-induced increases in escape latency in the Morris water maze in mice
Cayman Chemical DIpsacosIde B 10mg
A triterpenoid saponin with hepatoprotective activity; enhances acetaminophen-induced autophagy and inhibits acetaminophen-induced apoptosis in HepG2 cells at 0.5 µM; increases survival in a mouse model of acetaminophen-induced acute liver failure at 50 mg/kg
Cayman Chemical TheaflavIn-3-galate 10mg
A polyphenolic flavonoid with antioxidant, anticancer, and anti-inflammatory activities; scavenges singlet oxygen and hydrogen peroxide, as well as superoxide and hydroxide radicals (IC50s = 0.86, 0.45, 21.7, and 32.49 µM, respectively), in cell-free assays; is cytotoxic to, and induces apoptosis in, OVCAR-3 and A2780/CP70 ovarian cancer, but not non-cancerous IOSE 364 ovarian epithelial, cells at 20 and 40 µM; reduces oxazolone-induced EAr edema and serum and EAr levels of TNF-α, IFN-γ, and IL-12 in an oxazolone-sensitized mouse model of delayed-type hypersensitivity at 50 mg/kg
Cayman Chemical 1-O-CaffeoylquInIc AcId 10mg
A phenolic acid; binds the NF-κB precursor protein p105 (Ki = 0.007 µM); binds PD-1 (KD = 12.4 µM) and inhibits the protein-protein interaction between PD-1 and PD-L1 (IC50 = 87.28 µM)
Cayman Chemical McaAVLQSGFRK DnpKNH2tr 10mg
A fluorogenic substrate for SARS-CoV Mpro; Mca is released upon cleavage by SARS-CoV Mpro and its fluorescence can be used to quantify SARS-CoV Mpro activity; ex/em = 328/420 nm, respectively
Cayman Chemical CrostIdetrIfluoroacetAT s 10mg
A peptide substrate for Akt; corresponds to the amino acid sequence of GSK3 that surrounds the serine residue phosphorylated by RSK1 or p70S6K; also a substrate for SGK3
Cayman Chemical -PraeruptrIn B 10mg
A pyranocoumarin with diverse biological activities; inhibits RANKL-induced osteoclastogenesis of primary mouse BMDMs at 10 µM and LPS-induced NO production in RAW 264.7 macrophages at 100 µM; inhibits PAF-induced platelet aggregation in isolated rabbit platelet-rich plasma (IC50 = 50 µM) and contractions of isolated guinea pig ileum induced by histamine or leukotriene D4 (pD2s = 4.84 and 4.34, respectively); decreases ovariectomy-induced bone loss in a mouse model of osteoporosis at 10 mg/kg; reduces the number of tumors initiated by DMBA and promoted by TPA in a mouse two-stage model of skin carcinogenesis