Custom Peptides
Cayman Chemical ThIocolchIcIn 10mg
An inhibitor of microtubule assembly (IC50 = 2.5 µM); inhibits binding of colchicine to tubulin (Ki = 0.7 µM); inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM)
Cayman Chemical ArcaInsulfate 10mg
An NMDA receptor antagonist (IC50 = 9.13 µM); inhibits NMDA and glycine-induced inward currents in X. laevis oocytes expressing rat NMDA receptors (IC50 = 60.1 µM); impairs contextual and auditory fear conditioning in rats when administered post-training at 10 mg/kg, i.p.
Cayman Chemical ErythrodIol 10mg
A triterpene with diverse biological activities; induces relaxation of isolated rat aortic rings precontracted with phenylephrine (EC50 = 3.38 µM); inhibits the growth of HT-29 adenocarcinoma cells (EC50 = 48.8 µM); induces production of ROS and apoptosis in MCF-7 cells at 100 µM; topical administration reduces TPA-induced EAr edema and MPO activity in mice at 0.5 mg/ear
Cayman Chemical ICEC0942hydrochlorIde 10mg
A Cdk7 inhibitor (IC50 = 0.04 µM); selective for Cdk7 over Cdk1, -2, -4, -5, -6, and -9 (IC50s = 1.8, 0.62, 49, 9.4, 34, and 1.2 µM, respectively); induces cell cycle arrest at the G2/M phase and apoptosis in HCT116 cells; reduces tumor growth in MCF-7 and HCT116 mouse xenograft models at 100 mg/kg
Cayman Chemical MoexIprIlat 10mg
An ACE inhibitor and active metabolite of the prodrug moexipril (IC50 = 2.1 nM); prevents the estrone- or angiotensin II-stimulated proliferation of primary neonatal rat cardiac fibroblasts at 10 nM; reduces mean arterial blood pressure and increases the levels of atrial natriuretic peptide in ovariectomized mice at 50 mg/kg per day
Cayman Chemical CryptotnshInon 10mg
A natural quinoid diterpene that, at 10-20 µM, stimulates AMPK in C2C12 myotubes and activates p38 MAPK in DU145 cells; inhibits SHP2 in vitro (IC50 = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 cells; has a variety of anti-cancer actions
Cayman Chemical 6aMethylprednIsoLN 21hemI 10mg
A prodrug form of methylprednisolone; nanoliposomes containing 6α-methylprednisolone 21-hemisuccinate decrease disease severity in a rat model of adjuvant-induced arthritis
Cayman Chemical NMS-1286937 10mg
An inhibitor of Plk1 (IC50 = 2 nM); selective for Plk1 over Plk2 and Plk3 (IC50s = >10,000 nM for both); inhibits proliferation of A2780 cells (IC50 = 42 nM); halts the cell cycle at the G2/M phase in A2780 cells at 20-200 nmol/L and induces apoptosis; reduces tumor growth in an HCT116 mouse xenograft model at 60 mg/kg once per day; induces tumor regression in an HT-29 mouse xenograft model at 45 mg/kg in combination with CPT11
Cayman Chemical GBR 13069hydrochlorIde 10mg
A dopamine uptake inhibitor; selectively inhibits dopamine uptake over norepinephrine uptake in rat occipital cortex slices (IC50s = 40 and 800 nM, respectively); induces ipsilateral rotation and increases locomotion in rats at 2.5, 5, and 10 mg/kg; prevents 2’-CH3-MPTP-induced decreases in neostriatal levels of dopamine, DOPAC, and HVA in mice at 5 mg/kg
Cayman Chemical 3-IsomngostIn 10mg
A xanthone with diverse biological activities; an inhibitor of MTH1 (IC50 = 52 nM); inhibits aldose reductase (IC50 = 3.48 µM), AChE (IC50 = 2.36 UG/ml), and BChE (IC50 = 5.32 UG/ml); inhibits the growth of P. falciparum strains D6 and W2 in isolated and infected red blood cells (IC50s = 3.23 and 2.52 UG/ml, respectively); inhibits cyclin D2/Cdk4 and cyclin E1/Cdk2 (EC50s = 15.6 and 34.92 µM, respectively) and reduces viability of HCC1937 and HCT116 cells (IC50s = 59.9 and 47.4 µM, respectively)
Cayman Chemical ngIotensIn AtrIfluoroACTA 10mg
An AT1 and AT2 receptor agonist and active metabolite of angiotensin II; binds to AT1 and AT2 receptors in HEK293 cells expressing the rat receptors (IC50s = 0.29 and 0.12 nM, respectively, in radioligand binding assays); induces calcium mobilization in VSMCs (EC50 = 100 nM); increases the perfusion pressure in isolated perfused rat kidney (EC50 = 443 nM), an effect that can be reversed by EXP-3174; the plasma Ang A/Ang II ratio is increased in patients with end-stage renal failure; serum levels are decreased in patients with pulmonary arterial hypertension
Cayman Chemical MInoxIdIl Sulfate 10mg
A hair follicle stimulator and an active metabolite of minoxidil; binds to KATP channels in a biphasic manner in COS-7 cells expressing the human channel (IC50s = 0.62 and 0.96 µM); induces vasodilation in isolated rabbit mesenteric artery at 5 µM